R&D Projects Supported by NIH and CDC

National Institute of Health (1 R41 AI126971)

Title: 4-(Aminomethyl) benzamides as novel anti-Ebola agents

Duration: August 1, 2016-July 31, 2019

 

National Institute of Health (1 R41 AI127031)

Title:  4-Aminopiperidines as novel anti-influenza agents

Duration: June 1, 2016-May 31, 2019

 

Center of Disease Control (CDC, 1R43CK000495)

Title: Furopyrroles as novel anti-Ebola agents

Duration: Sept 30, 2016-Sept 29, 2018

 

National Institute of Health (1 R41 AI145727)

Title: Development of group 2 influenza A virus entry inhibitors

Duration: April 1, 2019-March 31, 2021

 

National Institute of Health (2 R42 AI126971)

Title: 4-(Aminomethyl) benzamides as novel anti-Ebola agents

Duration: August 16, 2019-July 31, 2022

 

National Institute of Health (1 R41 AI157095-01)

Title: Furopyrimidines as novel inhibitors of henipaviruses

Duration: January 11, 2020-December 31, 2022

National Institute of Health (1 R42 AI155039-01A1)

Title: Development of 4-(aroylamino)piperidine-based entry inhibitors as anti-influenza therapeutics

Duration: April 02, 2021-March 31, 2022

Publications

Wang Z, Kim J, Zhang P, Galvan Achi JM, Jiang Y, Rong L. Current therapy and development of therapeutic agents for lung cancer. Cell Insight. 2022. April; 1(2).

Cheng, H., Schafer, A., Soloveva, V., Gharaibeh, D., Kenny, T., Retterer, C., Zamani, R., Bavari, S., Peet, N.P., and Rong, L. 2017. Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor. Antiviral Research. 145: 24-32

 

Han, J., Perez, J., Schafer, A., Cheng, H., Peet, N., Rong, L., and Manicassamy, B. 2018. Influenza Virus: Small Molecule Therapeutics and Mechanisms of Antiviral Resistance. Current Medicinal Chemistry. 25:5115-5127. Invited Review.

 

Schafer Adam, Cheng Han, Lee C, Du R, Han J, Perez J, Peet N, Manicassamy B, Rong L. 2018. Development of Potential Small Molecule Therapeutics for Treatment of Ebola Virus. Current medicinal chemistry 25:1-14. Invited Review

 

Gaisina IN, Peet NP, Cheng H, Li P, Du R, Cui Q, Furlong K, Manicassamy B, Caffrey M, Thatcher GRJ, Rong L. Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir. J Med Chem. 2020 Mar 2;. doi: 10.1021/acs.jmedchem.9b01900. [Epub ahead of print] PubMed PMID: 32069052.

 

Antanasijevic A, Durst MA, Cheng H, Gaisina IN, Perez JT, Manicassamy B, Rong L, Lavie A, Caffrey M. Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor. Life Sci Alliance. 2020 Aug;3(8). doi: 10.26508/lsa.202000724. Print 2020 Aug. PubMed PMID: 32611549; PubMed Central PMCID: PMC7335401.

 

Hussein AFA, Cheng H, Tundup S, Antanasijevic A, Varhegyi E, Perez J, AbdulRahman EM, Elenany MG, Helal S, Caffrey M, Peet N, Manicassamy B, Rong L. Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus. Antiviral Res. 2020 May;177:104782. doi: 10.1016/j.antiviral.2020.104782. Epub 2020 Mar 25. PubMed PMID: 32222293; PubMed Central PMCID: PMC7243365.

 

Gaisina IN, Peet NP, Wong L, Schafer AM, Cheng H, Anantpadma M, Davey RA, Thatcher GRJ, Rong L. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225. doi: 10.1021/acs.jmedchem.0c00463. Epub 2020 Jun 17. PubMed PMID: 32490678; PubMed Central PMCID: PMC7671190.

 

Du R, Cheng H, Cui Q, Peet NP, Gaisina IN, Rong L. Identification of a novel inhibitor targeting influenza A virus group 2 hemagglutinins. Antiviral Res. 2021 Feb;186:105013. doi: 10.1016/j.antiviral.2021.105013. Epub 2021 Jan 8. PubMed PMID: 33428962.

 

Schafer A, Xiong R, Cooper L, Nowar R, Lee H, Li Y, Ramirez BE, Peet NP, Caffrey M, Thatcher GRJ, Saphire EO, Cheng H, Rong L. Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry. PLoS Pathog. 2021 Feb;17(2):e1009312.  doi: 10.1371/journal.ppat.1009312. eCollection 2021 Feb. PubMed PMID: 33539432; PubMed Central PMCID: PMC7888603.

Chen Z, Cui Q, Cooper L, Zhang P, Lee H, Chen Z, Wang Y, Liu X, Rong L, Du R. Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases. Cell Biosci. 2021 Feb 28;11(1):45. doi: 10.1186/s13578-021-00564-x. PubMed PMID: 33640032; PubMed Central PMCID: PMC7914117.

Amaya M, Cheng H, Borisevich V, Navaratnarajah CK, Cattaneo R, Cooper L, Moore TW, Gaisina IN, Geisbert TW, Rong L, Broder CC. A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery. Antiviral Res. 2021 Sep;193:105084. doi: 10.1016/j.antiviral.2021.105084. Epub 2021 May 30. PubMed PMID: 34077807.

Wang Z, Peet NP, Zhang P, Jiang Y, Rong L. Current Development of Glioblastoma Therapeutic Agents. Mol Cancer Ther. 2021 Sep;20(9):1521-1532. doi: 10.1158/1535-7163.MCT-21-0159. Epub 2021 Jun 25. Review. PubMed PMID: 34172531.